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Introduction to evidence-based practice for the health sciences

Appraise: review the evidence

Appraise: review the evidence

Once you have completed the searches you need to answer your question, the next step in the EBP process is to critically appraise the evidence you have found. Critical appraisal is the process of systematically analysing and evaluating the research methodology, data collection methods, and findings of a research study to assess its quality, credibility, and relevance to a specific clinical question (Burls, 2009).

By critically examining the evidence, you will develop an understanding of:

  • what treatments or interventions may work,
  • whether the research was conducted properly and reported accurately,
  • whether the benefits of an intervention or treatment could outweigh any potential harms or costs,
  • how to make evidence-based decisions when presented with different research findings.

Why should you critically appraise the research evidence?

Critically appraising the research evidence is important for a number of reasons, including:

  • Applicability to your practice: healthcare professionals implement evidence-based practices to improve patient care and outcomes. Critical appraisal prompts you to consider factors such as patient population and available resources, helping you to determine how applicable the evidence is to your clinical setting or question.
  • Identifying gaps and limitations: critical appraisal helps you to spot gaps or limitations in the published literature, helping you to refine your clinical question. 
  • Informed decision-making: by critically appraising the evidence base, you can make informed decisions and ensure that your practice is based on the best available evidence.
  • Validity and reliability: critical appraisal helps you to evaluate the quality of the evidence you use, ensuring that you can trust the research findings and apply them to your practice. 
  • Ethical considerations: ethical principles and practices are vital in healthcare. Critical appraisal helps you to assess whether the studies your practices are based on adhere to these principles and ensure that your practice respects patient autonomy and avoids bias. 

Critically appraising the evidence-base ensures that your practice is underpinned by high-quality evidence, aligns with ethical standards, and aims to positively impact patient care outcomes and service delivery.

Bias

What should you look for?

Bias

Bias refers to any factor that influences the study process or outcomes, resulting in conclusions that may not accurately represent reality. It can develop at various stages of a study, from the way participants are selected to how data is gathered, processed, and reported. Identifying potential bias is crucial when evaluating research in order to establish the study's credibility. There are many types of bias that can impact research studies. 

Type of bias Definition Example How to spot it
Selection bias Occurs when the study participants are not representative of the target population, leading to skewed results A study on speech therapy effectiveness that only includes children from high-income families may not reflect outcomes for lower-income families. Check if study participants were randomly selected and if inclusion/exclusion criteria were clearly defined by the researchers.
Performance bias  Happens when study participants or researchers change their behaviour due to knowledge of the study or treatment assignment. If a therapy study provides additional support beyond the therapy being investigated, to the intervention group, then the results may reflect the additional attention instead of the effectiveness of the therapy. Check whether the researchers assessing study outcomes were blinded and objective outcome measures were used.
Reporting bias Occurs when only certain results are reported, usually those that support a particular hypothesis or show significant findings. A pharmaceutical company might publish only the positive results of a new drug trial while not reporting trial results that showed no benefit. Verify whether all expected outcomes were reported, including negative or non-significant findings.
Funding and Conflict of interest bias Research outcomes can be influenced by who funds the study or the researchers' affiliations.  A study funded by a speech therapy company that concludes its new software is highly effective may be biased if independent studies have not confirmed the results. Check who funded the study and whether conflicts of interest were disclosed. 
Attrition bias Happens when study participants drop out at different rates between the groups, potentially affecting the validity of the findings.  If more participants in the control group drop out of a weight-loss study than those receiving an intervention, it could make the treatment appear more effective than it really is. Review drop-out rates and see if the researchers accounted for missing data.
Racial bias Occurs when study design, data collection, analysis, or interpretation is influenced by assumptions or systemic inequalities related to race, leading to misrepresentation or exclusion. A mental health study on university students finds stress as the main cause of depression but only includes White participants. It uses culturally biased screening tools and ignores systemic factors like discrimination. Findings are generalised, risking misdiagnosis and ineffective interventions for diverse populations. Check if diverse racial/ethnic groups are included and appropriately represented and whether research approaches and tools are appropriate to diverse populations. 

For additional information on the types of bias that can impact research studies, go to Oxford's Catalogue of bias.

Validity

Validity

In research studies, validity refers to the degree to which a research study accurately measures what it is intended to measure and that the results truly reflect what is being studied. Validity ensures that research findings are accurate, reliable, and applicable to real-world situations. 

  • Internal validity - Measures whether the research accurately shows that the observed effects can be attributed to the intervention or treatment being studied rather than other factors or biases. Factors that improve internal validity include randomisation, control groups, and minimising bias. 
  • External validity - Determines if the study's findings can be applied to real-world settings, other conditions, or different populations. A study with high external validity can be generalised beyond the study participants. 

Impact

Impact

The impact of a research study assesses its clinical significance and ability to influence real-world practice and decision-making. It considers whether a study's findings have practical applications such as:

  • Improving patient outcomes - does the intervention lead to better health or improved experiences?
  • Guiding clinical interventions - can the study findings be used to enhance treatments or services?
  • Shaping policies and guidance - does the research provide evidence for new policies or best practices?
  • Evaluating impact established whether the research contributes meaningfully to patient care, professional practice, and broader health and social outcomes. 
Visit the Getting started with stats page of this guide to learn more about interpreting basic statistics in research studies. 

References

References

Burls, A. (2009). What is critical appraisal? Hayward Medical Communications. https://www.whatisseries.co.uk

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